Finalist
DoctorDean
What I built.
sciencedev toolsagents
Dean Sherry
Cerebral Valley · Anthropic · 2026-07-07 to 2026-07-14
Built with Claude: Life Sciences
Public gallery: every submissionEvent page ↗
- Projects
- 299
- Winners
- 7
- With repo
- 88%
Winners
Finalist
Jaymin
I used Claude to train a protein language model that can generate an extremophilic version of any enzyme, maintaining its function, while allowing it to survive extreme temperatures, pH, salinity, etc.
science
Jaymin Patel
Finalist
Faith Ogundimu
Diffuse midline glioma is a paediatric brainstem cancer that is almost uniformly fatal: about ninety percent of children die within two years, and the first systemic drug, approved in 2025, does not cure.
healthscience
Faith Ogundimu
Finalist
About Trialign
About Trialign is a patient-facing clinical trial matcher for oncology.
health
Neil Wang, Jules Park
Finalist
Hippocampus AI
Hippocampus AI is the memory and reasoning engine for scientific discovery.
scienceagents
Finalist
Tina Lasisi
Many primates are sexually dichromatic — males and females are different colors.
science
Tina Lasisi
Finalist
Springbuilt
Hi!
healthscience
Shereen Lee
Motif
Motif is a molecular-biology workbench that runs inside Claude Science as a plugin.
sciencedev tools
Jacob Vogan
PerturbGate
PerturbGate is an open-data, reproducible pipeline that turns a genome-scale primary human CD4 T-cell Perturb-seq screen into evidence-gated mechanism hypotheses — not another ranking of hits.
sciencehealth
Margarita Soloshenko
SpatialScribe
SpatialScribe is a self-serve copilot for imaging-based spatial transcriptomics (Xenium, CosMx, MERSCOPE, and whole-transcriptome Atera).
sciencehealth
Paul Gueguen
Vellum
Vellum is a glass-box agentic ICD-10 coder.
healthfinance
Fareed Khan
Verastar
Verastar is a morning literature harness built by and for a busy vascular surgeon who can't read the hundreds of papers published in her field each month, yet can't afford to miss them.
healthscience
Marissa Famularo
SecondLook
SecondLook is a trust layer for an AI basal cell carcinoma detector, built for a dermatopathologist, Mohs surgeon, or dermatologist reading skin-pathology slides under real clinic load, where long days and fatigue nudge
healthvision
Edward Yi
Sam's team
built two open-source tools that solve problems I kept seeing in computational biology.
sciencedev tools
Samuel Bharti
CuraVar
CuraVar is a "show your work" assistant for classifying genetic variants.
healthscience
Husnain Arif
CBMR Multimodal
**What we investigated.** ML leaderboards present ranked models with narrow error bars, which reads as evidence of predictive strength.
scienceagents
Dewei Hu
G-perturb
G-perturb re-ranks drug targets from a genome-scale CD4+ T-cell Perturb-seq screen by whether each effect is dependable, not just by how large it is.
sciencehealth
Che Cheng
NOTE
NOTE: Please read the manuscript in github.
healthscience
Jaron Mohammed
Stanza
I built Stanza to chase a frustrating question: when a resistance mutation kills a cancer drug, can you get to a redesigned molecule in minutes instead of years?
healthscience
Ayush Kumar
Sabih
We mapped the causal control architecture of a human immune cell and used it to nominate druggable, disease-relevant targets.
sciencehealth
Syed Sabih ur Rehman
PaedScale
PaedScale — a starting pediatric dose from adult pharmacokinetics, with a cited rationale Most drugs are never trialed in children, so when a kid needs one that has no pediatric label, clinicians extrapolate the dose by
healthagents
Dhruvik Pandya
CisFalcon
AI now designs synthetic enhancers meant to switch a gene on in one cell type and stay silent everywhere else.
sciencehealth
Ubaidullah Shuaib
Cruciblees
Science has always started with people with a question, an idea, and the work to turn it into a finding.
scienceagents
Lucas Stoffl, Abhishek Thanki
Genome Therapy
Sequence-to-expression "oracles" (Enformer, Borzoi, AlphaGenome, Evo2) and the generative-DNA designers built on them all aim to predict how cis-regulatory DNA sets a gene's expression.
sciencehealth
Qihao Duan
Oocytezero
OocyteZero asks a concrete question behind a disease that affects up to 1 in 8 women: can today's DNA-reading AI models name the single causal base at an unsolved PMOS (polycystic ovary syndrome) genetic locus?
healthscience
Jose Contreras
Nick Lamb
When two well-run papers disagree, it is rarely because one of them is wrong.
sciencedev tools
Nick Lamb
CREative
To understand how Alzheimer’s disease reshapes the brain’s regulatory landscape cell type by cell type, I used Claude Science to analyze Droplet Paired-Tag data from 10 donors across the hippocampus and cerebellum.
healthscience
Protocol To Data
protocol-to-data turns a clinical trial protocol into a validated, analyzable synthetic SDTM dataset in one Claude-driven agentic loop.
healthdev tools
Chetan Tamballa
Meow
Immune checkpoint blockade (ICB) reactivates T cells to kill tumors and has transformed cancer treatment, but many patients don't respond.
healthscience
Shanshan Yin
Anuj Dev Singh
I tested a specific, high-stakes question for disease genetics: can today's best sequence-to-function deep-learning models (AlphaGenome, Borzoi, and the DeepSEA/Basset lineage) predict the DIRECTION — up or down — of a n
sciencehealth
Anuj dev Singh
Claudician
I built Clinical Digital Twin, an open-source R system (Shiny/plotly dashboard, plumber API, SQLite, and a Telegram bot powered by Claude) that gives clinicians in elder-care institutions a personalized, interpretable mo
healthagents
Daniel Gallardo
OPUS-ET-AGENT
OPUS-ET-AGENT: agent-conducted cryo-electron tomography Cryo-electron tomography (cryo-ET) is the only technique that resolves macromolecules at near-molecular detail inside intact cells.
scienceagents
Zhenwei Luo
Panoscope
Panoscope is a grounded interpretation layer over jazzPanda's spatial-transcriptomics output.
healthscience
Xinyi Jin
Everyone
Everyone builds bigger models to predict what a gene knockdown does.
science
Lukas Weidener
Wen Group
Cell-Type-Resolved Chromatin Effects of AD/PD Variants: DNA Language Model vs.
science
DeepPro-v2
DeepPro-v2 is a multi-view, multi-backbone deep learning model for prokaryotic promoter prediction across 23 species.
science
Johnson V
Evolution Arena
Evolution Arena is an interactive 3D WebGL survival game that turns evolutionary biology into something you can experience rather than simply read about.
education
JJ Ben-Joseph
Odola Labs
I created a workbench where you can name a protein and specify an objective in simple terms, and the agent will then manage the entire campaign.
scienceagents
Chinmay Pala
Kilian Maire
Repertoire2Structure (R2S) is a multi agent pipeline, orchestrated by Claude, that turns a raw 10x single cell TCR repertoire into QC'd predicted TCR to peptide MHC structures for its top clonotypes, with honest specific
scienceagents
Kilian Maire
Molaro
Molaro is a next-generation molecular dynamics environment built as a VS Code extension.
sciencedev tools
Dominic Fico
Markus Sommer
Determining whether a cancer patient responds to immunotherapy, detecting contamination in food and water, measuring mitochondrial membrane potential: scientists depend on flow cytometry.
healthscience
Markus Sommer
Myomatlas
Myomatlas is an open, image-based decision-support tool for abnormal uterine bleeding, one of the most common and most under-addressed problems in women's health.
healthvisionagents
GeneGround
GeneGround is a claim-level grounding layer for AI-generated omics interpretations.
scienceagents
Rhea Zhou
Clonal Compass
Clonal Compass is a single-cell immune-repertoire co-pilot for paired scRNA-seq + TCR-seq data.
science
Trish Whetzel
Litmus
Litmus reads a scientific paper and tells you how much to trust it before you build on it.
science
Aarush Agarwal
David Fraile Navarro
GLP-1 drugs like Ozempic are among the world's most prescribed — and in 2023 regulators opened suicide investigations after adverse-event databases lit up, even though the randomised trials showed no such risk.
healthscience
David Fraile Navarro
Cellarium
Cellarium is a tool for asking questions of the whole-cell model of E.
scienceagents
Evangelos-Marios Nikolados, Filippo Menolascina
Enactome
Enactome is a connectome-constrained simulation platform that loads the BANC Drosophila connectome (composed of 158,262 neurons, 3,990,039 synapses), signs each synapse by its presynaptic transmitter, and evaluates circu
science
Mehmet Kerem Turkcan
Clinibrium
Clinibrium is a clinical decision-support co-pilot for the otoneurology clinic, developed with a subspecialist otolaryngologist.
healthagents
Manuel Pena Zuniga
Litmuz
Litmuz is a claim-level verification layer for life-sciences research agents.
scienceagents
Jophin George Joseph
I built Mechanome, a physics-first inference engine that recovers mechanical forces in cells from protein structure and microscopy.
science
Jophin George Joseph
Provenance Gate (solo team)
I investigated a failure mode of agentic science: as an agent forks approaches, revises an upstream step, and re-runs, a final result can quietly come to rest on stale or version-conflicting inputs.
sciencedev tools
Sergey Aganezov
Seqcolyte
Seqcolyte is an open-source, protocol-aware platform for sequencing quality control and root-cause diagnosis.
sciencedev tools
chilam p
The Weavers of Fate
Norn (https://norn-five.vercel.app/) is a variant-interpretation copilot for clinical geneticists.
healthscience
Vignesh Nagarajan
futurelarry
## Project description — agent-eln ### What I built **agent-eln** is an AI-native lab operating system: a single git repo that unifies an Electronic Lab Notebook (ELN), a Laboratory Information Management System (LIMS),
scienceproductivity
NeuroVas Copilot
NeuroVas Copilot: An Interrogable 3D Aneurysm Reasoning Tool What we built Unruptured brain aneurysms present a difficult decision: treat now with clipping, coiling, or a flow diverter, or monitor and wait.
healthvision
Garvit Jain, Ronuk Gadamsetty
Sourced
Sourced is a provenance-first medication safety review tool for clinicians and pharmacists.
healthsecurity
Railly Hugo
Persona
Persona is a persistent, always-on synthetic researcher for the biomedical literature.
scienceagents
Aryan Singh
NUDGE
NUDGE — an "honesty engine" for AI-driven science.
science
Nicholas Roy
Noozra
Two open-source tools, built with Claude, that catch expensive biology failures early — on public data, as decision-support (never a diagnosis).
scienceagents
Cardio21
PYRIN-PLAQUE Digital Twin investigates whether MEFV/pyrin inflammasome biology can be separated from the saturated NLRP3 atherosclerosis story and mapped to human plaque cell states using only public data.
sciencehealthagents
Ibrahim Halil Tanboga
INTEGRITY
INTEGRITY is a forensic scanner for life-science manuscripts.
sciencedev tools
Javier De Jesus
Historify
Most people's medical history is a pile of PDF lab reports — one per clinic, each in its own layout, none of them talking to each other.
healthvisionagents
David Castro
The chief dawgs
We investigated whether a genome-scale CD4+ T-cell Perturb-seq screen contains reproducible regulatory architecture beyond ranked hits, statistical noise and connectivity hubs We built a quality-audited regulator × gene
science
Santiago Silva
PaperTrail
▎ PaperTrail is a provenance-grade verification platform for clinical-evidence claims.
healthscience
arhan subasi
Discoverybytes
Co-localization of signaling molecules to a stable cell-cell interface is a key prerequisite for signaling in systems such T cell activation.
sciencehealth
John Proudfoot
Mickey Pentecost
Traumatic brain injury and inherited genetic risk both raise the odds of Alzheimer's, but no one had shown they act through the same mechanism.
healthscience
Mickey Pentecost
TrustCheck
Problem.
scienceagents
Chunyi Liu, Assaf Magen
Specimen Casebook
Specimen Casebook is auditable data reconciliation for biodiversity collections.
sciencedev tools
Keigo Takahashi
enTrust
What it is.
healthscience
Sujit Shelar
CellVerdict
CellVerdict is a multi-method consensus annotator and trust layer for single-cell RNA-seq data.
sciencehealth
junseong kim
Kinga Zielinska
We set out to build a machine-learning classifier that predicts a clinically meaningful vaginal-microbiome state from a baseline metagenomic profile, using only public data.
healthscience
Kinga Zielinska
Ash0723
RegScope- Now available at https://auronideep777.github.io/RegScope/ https://github.com/auronideep777/RegScope The short version: RegScope is a small suite of browser-based tools that do one connected thing: read a piece
healthscience
Auroni Deep
Claudia & Claude(ius)
Right now, 57 million people are living with dementia — one more begins to forget every three seconds.
healthaccessibility
Klaudia Kromolowska
FACET
Scientists in different roles ask the same question and need different answers.
scienceagents
Keerthi Harikrishnan
FlexScience
Spatial perturbation transcriptomics aims to measure how a genetically edited cell affects surrounding tissue.
science
Tianxiang Dai
Strata
Strata is a living meta-analysis like tool for the teams who depend on evidence.
healthscience
e11
Clinical datasets that could move research forward sit unused because two questions are hard to answer together: is this use consented, and is the data de-identified enough to share?
legalhealth
Abhishek Srivastava
IMMUNA
In one week, I turned a biological question into a journal-ready paper and reproducible biomarker.
healthscience
Fridolin Haugg
Demir Ege Ortac
I ran my tool on published, peer-reviewed data from the Wilbrecht lab at Berkeley (DANDI:001340, dopamine in the nucleus accumbens during reward learning).
sciencehealth
Demir Ege Ortac
CanCell
I built an interactive analysis that separates cell-state composition from cell-intrinsic gene regulation in 1,714 acute-leukemia RNA-seq samples.
healthscience
Onur Karakaslar
Ruth-Anne Pai
I took one disease from idea to an investable program in a week and then turned that workflow into open AI agents for any disease.
healthagents
Ruth-Anne Pai
OmniGate
I built OmniGate, a tool that answers questions about real single-cell perturbation data in plain English, and shows its work.
scienceagents
Kian Khooban
Tuna Birgun
omicau (Omics Audit) is a reproducible, leakage-safe command-line tool, with an optional no-code web interface, that audits a multi-omic dataset before anyone trusts a predictive result.
healthsciencedev tools
Tuna Birgun
Phebe
I created PKU Commons, a framework for developing and maintaining a phenylalanine estimating app usable for both managing the dietary requirements of PKU as well as clinical and research purposes.
health
Nina Kilbride
Concinnity
We built a directional readout of organelle dynamics.
sciencehealth
Taras Nazarov
Project
Project: We benchmarked whether Boltz-2 (an AlphaFold-class structure predictor) can substitute for a binding measurement, testing two complementary questions across two systems: does its confidence score rank affinity (
science
Ryeogang Son
TFModulators
Conserved gene co-expression & regulatory networks across vertebrates — abstract One of the holy grails of biology is to understand how 1 genome can make all the different cell types, each with a unique regulatory networ
science
Brandi Cantarel
CoronaryAtlas
The research question.
healthscience
Narayana Sarma Singam
BiotechOS
BiotechOS — an operating system for running a drug-discovery pipeline.
productivityagents
Sourav Bandyopadhyay
Basecase
I built Basecase, an AI-assisted genomic research workspace that connects natural-language questions directly to an interactive genome browser.
scienceagents
InsideOut Bio
Every approved atopic dermatitis (AD) drug blocks the type-2 pathway from the outside: injectable antibodies against extracellular cytokines.
healthscience
Sayane Shome
Bench to Biobank
Autoimmune drug discovery often fails when a gene that looks important in a cell experiment doesn't hold up in real people.
healthscience
Yukang Jiang
Aging Lab
What I built.
healthscience
Sungwon Jeon
Team SyL
In this project, we established an automated pipeline that seamlessly generates explicit-solvent molecular dynamics (MD) ensembles directly from SMILES inputs, extracts the full distributions of 3D descriptors, and enabl
science
Sangyeon Lee
Glioma Copilot
Glioma Copilot helps a neuro-oncology clinician and, through them, the patient - decide whether a clinical trial fits this specific glioma patient.
health
Tanja Hann
Most drugs for autoimmune and inflammatory disease work by blocking a cytokine everywhere, all the time.
healthscience
Brakepoint
Brakepoint is a genome-scale discovery engine for the next generation of cancer-immunotherapy drug targets.
healthscience
Chengchen Duan
Team Jack
Living Protocol Copilot A grounded, safety-first copilot for wet-lab protocols What I built Living Protocol Copilot is a web application that transforms static laboratory SOPs into structured, risk-aware “living protocol
scienceproductivity
Orphan Finder
Orphan Finder: reliability-aware target prediction for natural products, drug repurposing, and antimicrobial resistance.
healthscience
James Martin
Mosaic
Mosaic is an MCP server for preclinical target diligence.
healthagents
Sourabh Nyalkalkar
ai星星
What we investigated.
healthscience
Seishin Sakai
SALUS Zero
SALUS Zero is a clinical training simulator and bedside decision companion for medicine where nothing is available.
healtheducation
Sahin Parlak
NeoVUS
NeoVUS is a point-of-care tool for NICU clinicians who hit a variant of uncertain significance (VUS) in a neonatal genomic report.
healthscience
Moonyeon Oh
Sharab A
Journals now require that Methods declare RRIDs for antibodies, authentication for cell lines, and animal-rigor reporting.
sciencedev tools
Sharab Ahmad
Ritz
What I built.
healthagents
Ritu Chakrawarty
BibimbapKiller
What if a model could say the one word every drug-discovery pipeline needs but no other tool can utter — "unreachable"?
science
HISTORA
HISTORA is a non-diagnostic, agentic clinical-research navigator built with Claude Code for a clinical/translational researcher.
healthscience
Matias Molinas
Xiao
Background & motivation Mesothelioma is an aggressive, asbestos-linked cancer of the pleura with poor prognosis and few effective therapies.
healthscience
Wayfinder
Wayfinder is a hypothesis referee.
scienceagents
Dayanjan Wijesinghe
Ken Kamiya
morphoDE asks a deliberately simple question: where two cell types meet, the boundary bulges outward in some places and caves inward in others—do the cells on a bulge express different genes than the cells in a dent?
science
preCaution
Early in a routine lab protocol, piranha acid is prepared, used, and its spent waste poured into an acid waste carboy.
sciencehealth
Yuvraj Gupta
Alex Maier
We tested a timely scientific question: Does the brain (neocortex) fundamentally compute predictions (so-called predictive coding)?
science
Proteins
Proteins are spelled in a twenty-letter alphabet, and every one of those letters is an ordinary Roman letter.
science
Thomas Stranzl
Han Wei Tan
Most "AI made a discovery" claims collapse the moment someone asks for a control.
science
Han Wei Tan
PlaqueQTL
PlaqueQTL builds a cell-type-resolved eQTL resource for atherosclerotic plaque entirely from public single-cell RNA-seq — no new sequencing, no genotyping array.
healthscience
James Hilser
OnLabel
OnLabel is a self-verifying OTC medication-safety assistant for US consumers.
health
Michael Rothrock
What I built: I built BioSurface Audit, a deterministic tool that verifies the claims in an AI‑assisted single‑cell / Perturb‑seq analysis.
sciencedev tools
Michael Rothrock
Richard Zhu
What I investigated: I used the EvE Bio "pharmome" — a single-laboratory dataset measuring 1,397 approved drugs against 256 human targets (kinases, GPCRs, nuclear receptors) under one consistent framework — to ask two qu
sciencehealth
Richard Zhu
Negaverse
Negaverse is a Python toolkit for generating biologically informed negative datasets for protein–protein interaction models.
science
Bailin Zhang, Igor Gerasimov
Throughline
This is Throughline, a workbench built for patients and families suffering from a rare or chronic illness.
health
Linus Hansen
genetic_drift
I used the genome-scale CD4+ T-cell Perturb-seq atlas from Marson/Pritchard labs as an empirical genotype-phenotype map to ask how the architecture of the T-cell gene regulatory network shaped which Neanderthal variants
science
Alexandre Gouy
Cadence
Cadence is an AI copilot for the Learn phase of the synthetic-biology Design–Build–Test–Learn (DBTL) cycle.
science
Melik Demirel
ClinVal Validator
ClinVal Validator is built for one named user: the clinical-AI researcher who has trained a medical-imaging model and needs to know whether the reported AUC is real or an artifact of how the data was split.
healthscience
Vitalii Babenko
AxeCap
The user I built for is a genetic counselor holding a variant of uncertain significance in a regulatory region.
healthscience
Krishna Venkatesh
ShiftScope (solo)
ShiftScope compares any two single-cell populations, measures how far apart they are, finds the genes driving the difference, and ranks which genes to test next.
science
TransBench
TransBench turns a clinician's bedside observation, written in plain words, into a grounded, testable, bench-ready computational experiment.
healthscience
Kayomarz Darukhanawalla
A Class-I Act
HLA class I molecules sit at the center of a trade-off: the same allele that helps T cells kill a tumor may also raise autoimmune risk.
healthscience
Rebecca Nadler
Citera
Citera is a trust layer for AI-generated clinical regulatory documents.
legalhealth
Husein Indra Kusuma
Spinal injury
Globally, over 15 million people are living with spinal cord injury.
healthscience
Tien-chen Lin
Tim Lantin
Aging research is rate-limited by long iteration loops; it may take years or decades to know if an intervention has any effect.
healthscience
Pls let me win
What I built.
science
Alnur Kengesbay
Builder_QXY
Target selection is one of the earliest and most expensive decisions in drug discovery.
sciencehealth
Qiao Xuanyuan
eraya
Most immunogenomic models predict T-cell receptor–peptide binding.
sciencehealth
Pardeep Singh
chroma-code
regulatr — cell-type-aware non-coding variant prioritization What we built.
sciencehealth
Tarun Naithani
Human Phenotype Project (HPP)
I built the Claude Human Phenotype Project (HPP) Research Harness, a paper-calibrated, local-first research environment for private biomedical cohorts.
scienceproductivity
Hagai Rossman
ParadoxMap
I set out to test whether the IL-23/IL-17 therapeutic paradox — the same pathway helping in one organ and harming in another — has a measurable tissue-intrinsic signature in public single-cell atlases, using a preregiste
sciencehealth
PORTRAIT
PORTRAIT turns population health data into a per-patient passport - calibrated position, honest uncertainty, and what genuinely stands out - and refuses when the data cannot support a description.
healthscience
Daniela Oehring
EvolvingScholar
EvolvingScholar is an AI "research trainee" that learns the way a real medical trainee does — mentor-guided and improving across a *sequence* of gene–disease projects.
scienceeducation
Basepair
Basepair watches for one specific kind of preventable mistake.
health
Tyler Gibbs
Zeyu YANG
Disease predisposition arises from complex, multivariate gene regulation, yet conventional approaches typically nominate a single target gene and fail to capture the underlying regulatory network.
sciencehealth
Octopus
Octopus is a wet lab operating system.
scienceproductivityvoice
Clement Djezvedjian
Mightytreefolk
Why it matters.
science
Peter Thompson
Traxome
Traxome is a deterministic biomedical interpreter: it turns any symptom, gene, variant, or drug into a fully-sourced evidence dossier for patients, clinicians, and researchers.
healthscience
Kenneth Kusima
Cogworks
We built An Agentic Interface Over Existing Wet Lab Equipment Most lab equipment today is very difficult for researchers to use.
robotics/hardwarescience
dhruv agarwal
Natioan taiwan university hospital Cancer center
What we built: A genome-scale CRISPRi Perturb-seq screen in primary human CD4⁺ T cells turned into a working target-discovery system — not just an analysis.
sciencehealth
Hsiangwei Huang
DMV Petri Dish
Synthetic lethality is one of the cleanest routes to targeted cancer therapy, yet it remains understudied, and most cancer-screening data sits siloed behind deep expertise.
healthscience
Matthew Zamora
MMC
MMC - the Mechanistic Model Compiler AI models that predict what happens when you switch off a gene have a problem: the good ones are black boxes, and they still barely beat a linear baseline (Ahlmann-Eltze, Nature Metho
scienceagents
Anees Ahmed Mahaboob Ali
RAFLab/histo.fyi
I built a well curated dataset and then used it to answer 8 key scientific questions.
science
Chris Thorpe
e-nios
I carried out a research study, written up as a manuscript, on one of the hackathon's suggested datasets: a genome-scale atlas of what happens inside human immune cells when each gene is switched off.
sciencehealth
Eleftherios Pilalis
SeqIntel
SeqIntel turns a patent name into a validated sequence dossier, in minutes instead of hours.
legalscience
Rachit Thariani
KatalistSeek
KatalistSeek — a grounded reasoning layer over fragmented enzyme/reaction databases.
science
Jimmy Ouellet
K-Vector
I asked whether tissue-specific AAV regulatory elements could be identified systematically from public single-cell chromatin data, and whether their mouse-to-human translatability could be predicted before any wet-lab wo
sciencehealth
Karina Herlambang
SurvivalLadder
SurvivalLadder is an open-source screening tool — ten Galaxy tools, a Snakemake pipeline, and a Shiny app, all calling one identical R analysis core — that tests a user-defined geneset, a directional _UP/_DOWN signature,
sciencehealth
Sergio Oterino Sogo
Ray
Recent progress in mass spectrometers and softare drive protein identification from a single HeLa cell to more than 6000.
science
Lynx
Human accelerated regions (HARs) are widely interpreted as developmental enhancers, and human-specific substitutions are known to alter their enhancer activity and transcription-factor binding — but systematically only i
science
The Amplicons
We are two medical oncologists in London who code.
healthscience
Jie Lam, Adam Pennycuick
Arya
What I built: Ratify convenes diverse AI "labs" (each a small crew of persona-driven agents (a PI, members, and a critic)) running on different Claude models and seeded with a distinct scientific worldview to attack one
agentsscience
Grounded Genomics
I built a benchmark and a prompt-level "closed-world grounding" layer that measurably reduces hallucination when an LLM writes investigation summaries for genetic variants of uncertain significance (VUS).
healthscience
Fernando Rodrigues
Signal Reversal · T-cell Reversal
We asked a simple question of a genome-scale CRISPRi Perturb-seq screen of primary human CD4+ T cells (Marson & Pritchard labs): which single-gene knockdown pushes a T cell's transcriptome opposite to active autoimmune d
sciencehealth
Ze Yu, Dinesh Ravindra Raju
PPInteractors
One-sentence summary: I rebuilt the SARS-CoV-2 host interactome from the Krogan lab's raw AP-MS data using a novel updatable confidence score that lets structural and chemical evidence rescue borderline interactions, and
sciencehealth
Pedro Miguel Belio Mairal
Jaiaaryan
WHAT WE BUILT • OCTB (Optical Compatibility Test Bench) — try a camera/lens/light swap in software before buying hardware, and prove the instrument still gives the same answer.
sciencerobotics/hardwarevision
Jaiganesh Srinivasan
Luvia
Enormous AI spend goes into building biomedical knowledge graphs — and almost all of it is private or paywalled, rebuilt from scratch behind every company's walls and stale within a year.
scienceagents
Elis Samskog
BALL-RL
I built BALL-RL: Bayesian Anchored Latent Learning for Reinforcement Learning, a framework for learning personalized treatment policies when the clinically meaningful patient state is measured only intermittently.
healthscience
Jason Gibbons
TrialBridge - GlobalTrialBridge.com
What I built.
healthscience
Angelo Orru Neto
Metavert
Aitiome grades whether an environmental chemical has mechanistically-supported links to Parkinson's or Alzheimer's.
healthscience
Conduction Lens
Cardiac models are routinely fit to an ECG and their conduction parameters reported, but a prior question is rarely asked: which of those parameters can an ECG actually determine?
healthscience
Ricardo Garcia Ramirez
Team Glass Box
I built HAR-annotator, a glass-box pipeline for ranking Human Accelerated Regions — short stretches of DNA that stayed frozen across mammals for a hundred million years, then changed fast only on the human lineage, makin
sciencehealth
Natalie Chen
Hokie
What I built Clinical trials fail for predictable reasons.
healthagents
Ragul Seetharaman
vcf2report - gbbarra
vcf2report turns a raw exome VCF + the patient's phenotype (HPO terms) into an auditable, clinical-grade ACMG variant report — locally, offline, in seconds.
healthscience
Gustavo Barra
GroundTruth
What I built.
healthlegal
Victoria Wang
Structureless
Heart failure switches off OPLAH—a protective enzyme that clears a toxic metabolite—and no one had mapped where its known activator binds because OPLAH has no solved structure.
healthscience
Jose Esquivel
T-CTRL
Perturbation screens often rank genes by effect size, so a gene that changes many transcripts can be mistaken for one that actually controls cell state.
sciencehealth
Aimie Garces
Most new drugs fail, and the most expensive mistake is made years before a trial begins: choosing the wrong target (the specific protein a drug is designed to act on) for a disease.
healthscience
Aimie Garces
4nY4
Thirteen real BCG trials.
science
Anya Chueayen
ChannelScope
ChannelScope builds standardized, provenance-tracked context-graph objects for multi-omic biology — the structured groundwork that purpose-specific "omic" models need but rarely have.
sciencehealth
Rajiv Sangle
Representation Learning Duck
I have found a principled way to recover known and find new drug targets using the t-cell perturbation data for any disease whilst highlighting the interpretability of how those drug targets affect the proceeding biologi
sciencehealthagents
Dylan Setiawan
Victims of Optimization
The same search that produces adversarial examples—driving a model’s prediction up by making small changes to its input—can be turned into a tool for designing biological sequences.
sciencesecurity
Ajay Rangarajan, Jeyashree Krishnan
AstroOmix
AstroOmix is a Claude-powered research application for analysing space-biology data without overstating what limited datasets can support.
sciencehealth
Yoga Mithra Senthil Kumar
VPS
VPS - Variant Priority Score Current genetic-testing tools (ClinVar, InterVar, Franklin) can only classify variants that already exist in reference databases - roughly 80% of which are European-ancestry.
health
Nirmala Kadali
Oxphos
Exercise interventions offer profound systemic benefits, yet patient adherence remains a major clinical hurdle.
healthscience
Steve Hershman
Claymore
Claymore is an autonomous experimentation platform that gives scientific laboratories a persistent intelligence layer capable of conducting research on their behalf.
sciencerobotics/hardwareagents
Rikhil Tanugula, Rikhin Kavuru
n = 3, and Proud
Everyone building research agents runs into the same quiet question: once you have one, how should you set it up to do its best work?
scienceagents
Fabian Baezner
The Nineteen
## What we built / investigated We mined a genome-scale CRISPRi Perturb-seq atlas of about 22 million primary human CD4⁺ T cells to discover **novel drug targets**.
healthscience
Qiuchen Meng
Akhi's Achilles
Drug-resistant infections kill ~1.27 million people a year, and the hard part isn't naming a resistance gene — it's finding the reversible opening resistance leaves behind.
healthscience
Akhi Chappidi
Atlas
Atlas: every lab has a taste.
scienceproductivity
Ellen Schrader
AGEFOLD
AGEFOLD — A CONVERSATIONAL AI TO DECODE THE BIOLOGY OF AGING WHAT WE BUILT AgeFold turns a massive structural-proteomics dataset into something anyone can talk to.
sciencehealth
Xiaojing Sui
Redline
Single-cell RNA-seq conclusions fail peer review on the statistics while the biology holds up.
sciencedev tools
Pablo Manjarres
Coco and the Cancer-naughts
The bottom line: An AI agent that reads why an approved cancer drug failed a tumor — then designs a new antibody–drug conjugate (ADC) engineered to dodge that exact resistance.
healthscience
Lance Cadang
Upstream Team
What we built / investigated.
healthscience
Duck-Kyun Yoo (Team DK)
Germinal-center (GC) selection is almost always modeled along a single axis — antigen affinity.
healthscience
Duck-Kyun Yoo
Dynamics-aware-FeatureDock
Structure-based machine learning has ridden one wave: AlphaFold made static structure cheap and universal, and models like FeatureDock, Boltz-2, and DiffDock-L now predict binding from a single frozen pose.
science
Andres Lira, Natesan Mani
Rare Events
Protein conformational rates are hard to compute: the transitions are rare, so brute-force molecular dynamics almost never sees them.
science
Michael Kim
Lab Brain for Claude Science
I built Lab Brain, a tool that turns any biomedical lab project — its code, slides, data, papers, and notes — into a shared knowledge base that both Claude Science and Claude Code can read and write.
productivityscience
Sriram
This project presents a causal-structure-oriented, interpretable pipeline for modeling influenza (H3N2) antigenic distance from hemagglutination-inhibition (HI) data and HA sequence alignments.
sciencehealth
sriram vijendran
overlake.bio
I built Spacefarer Phenome, a genetics-first computational drug-discovery pipeline for spaceflight physiological stress, anchored on bone mineral density (eBMD).
sciencehealth
Rakhan Aimbetov
Let's fight cancer!
I built DN-Isoform Scout, an end-to-end computational proof of concept for discovering an underexplored class of cancer mechanisms: dominant-negative proteins that lose their normal function but retain the ability to ass
healthscience
Mateusz Mendel
Speciate
Speciate is an automated pipeline that turns a TEM micrograph of gold nanoparticles into the three numbers a nanoparticle lab needs on every batch: mean size, size distribution, and — the hard one — how aggregated the pa
science
Eun Sohl Koh
Dr. Alexander King
sc-referee automatically checks single-cell analyses for statistical mistakes that commonly slip through analysis and review.
sciencedev tools
Alexander King
Anchor
Anchor is a retrospective reproducibility agent for bioinformatics.
sciencedev tools
Maxime Blum
Reelin' from Alzheimer's Disease
Which neurons die first in Alzheimer's, and why those?
healthscience
Tamara Vasilkovska
CADENCE
CADENCE makes Parkinson's disease trials smarter and more cost-effective.
health
Joanna Dragich
Akshay
AI-predicted protein interactomes from AlphaFold-Multimer are now published as catalogues of "high-confidence" complexes and mined for drug targets.
sciencehealth
Akshay Kumar
AIstanbul Research Group
Clinical geneticists interpreting a patient's DNA constantly hit "Variants of Uncertain Significance" (VUS): changes where the evidence isn't enough to call them safe or harmful.
health
Virtual Heart Team
Complex revascularization — left main, multivessel, frailty — sits in genuine equipoise.
healthagents
MATIAS IGNACIO PINCETTI SAUTEREL
YC
We built the first world model of the cell — and, we believe, the first to unify all four of its axes into one shared state.
science
Yuchan Lee
Cancer crusher
What I investigated My PhD work showed that inhibiting the p38 kinase in mouse models of breast cancer sensitizes tumors to immune checkpoint therapy, and that it shifts the CD4+ T cell compartment away from immunosuppre
healthscience
Priyanka Rajan
VERITAS
VERITAS is an independent verifier for AI-generated single-cell findings.
sciencedev tools
Sreenath Menon
Tanvi Sinha
Tanvi Sinha is an experimental cardiovascular biologist at UCSF.
sciencehealth
Jan Lebert, Tanvi Sinha
AI4Cosmetics
I built the QSAR Cosmetics Skill for Claude & Claude Science to accelerate the safety assessment of cosmetic ingredients.
healthscience
Nicoleta Spinu
BGCFlow
BGCFlow is the standard pipeline for mining biosynthetic gene clusters (BGCs) across bacterial pangenomes, but its output is hard to interpret without expert time, and every novelty-relevant stage (antiSMASH, MIBiG, Pfam
science
Kayla Azima
GlycoWorks
What I built: GlycoTwin, an open mechanistic digital twin connecting a bioreactor knob to the antibody's Fc N-glycan — a quality attribute governing potency, half-life, and immunogenicity.
science
Chadakarn Sirasitthichoke
Anveshar
Anveshar is a reproducible research workbench for rare cancers, built to run from inside Claude Science.
healthscience
Dig Vijay Kumar Yarlagadda
Intron
This project analyzed an in-vivo single-cell CRISPR Perturb-seq screen of tumor-infiltrating CD8 T cells (Zhou et al.
science
Canyon
A logic-gated target-discovery pipeline for triple-negative breast cancer (TNBC).
healthscience
Claim Check
claim-check — a reproducibility auditor for agentic single-cell analysis.
sciencedev tools
Mira Arguelles
Shadi Shafighi
### What I built and investigated Regulatory-variant prediction models are commonly evaluated against massively parallel reporter assays, or MPRAs, as though the assay were direct ground truth.
sciencehealth
Shadi Shafighi
Sakintori
We built The Human Branch: a Claude Code agent that drives Claude Science as a headless lab and enforces the scientific method in code, so it cannot fool itself into calling a gBGC artifact a human innovation.
scienceagents
dbCAN-coder
We built dbCAN4-advanced, an end-to-end research and software platform for annotating fungal carbohydrate-active enzymes, or CAZymes.
science
Xinpeng Zhang
FluxForge
FluxForge is a disease-agnostic, Model Context Protocol (MCP) server that fuses primary literature, regulatory/PPI networks, and genome-scale metabolic models into an executable CRISPR gene-dependency and drug-target dis
agentssciencedev tools
MutationRx
MutationRx turns an unreliable computational method into a decision an oncology researcher can act on, by pairing physics with judgment.
healthscience
Ricardo Perez Castillo
AgingPrint
AgingPrint is a perturbation-informed immune aging clock that decomposes CD4+ T cell aging into three independent biological programs: pro-aging transcription, anti-aging transcription, and naive T cell composition.
healthscience
Jackson Schumacher
PertEMA
PertEMA is a post-hoc, model-agnostic reliability layer for single-cell perturbation-effect predictors.
science
Bishal Shrestha
Iaso
Iaso helps clinicians and patients recognize and navigate interventional options for severe cancer pain that persists despite escalating medication.
health
chromagentic
**Agentic Chroma is an MCP server that gives an AI agent the role of a human operator at a Waters chromatography workstation.** From any MCP-capable Claude client, a researcher runs liquid-chromatography experiments in p
sciencerobotics/hardwareagents
Selective Th2
I'm a backend/infrastructure engineer at Uber with no wet-lab background.
scienceagents
Shiven Tripathi
wguesdon
Which pair of cell-surface proteins marks prostate cancer cells while sparing every healthy human cell type?
healthscience
William Guesdon
CAR-DWK
Please check the final report on the GitHub repo!
healthscience
Dongwoo Kim
SVBench AI
SVBench AI is a Claude verdict layer for structural-variant callers.
sciencedev tools
Ramanandan Prabhakaran
emberwhirl-solo
I built PerturbScope, a dashboard that helps wet-lab biologists, clinician-scientists, and hybrid researchers turn large CRISPR Perturb-seq screens into reviewable target shortlists.
scienceproductivity
Yu-Tian Xiao
Orchestrated Biosciences
Tumor mutational burden (TMB) is our best predictor of immune checkpoint blockade (ICB) response, yet it's only modestly accurate (AUC ~0.6) and reads DNA alone.
healthscience
Lab Voice
Labs buy pipetting robots and then barely use them, because using one means writing code.
robotics/hardwarevoice
Ainur Nygmet, Junchen Lu
Piotr Kulesza
A lab protocol is a document.
educationvoice
Piotr Kulesza
F15 VCell
We worked on the Arc Institute Virtual Cell Challenge: given a gene knockdown, predict how the cell’s expression profile changes.
scienceagents
Petr Berlizov
MIMIC
We carry ~100x more microbial genes than human genes (~3.3M vs ~20,000), and we already know microbes signal to us in chemistry — SCFAs->GPR43, bile acids->FXR/TGR5, tryptophan->AhR, some even mimicking our own ligands (
sciencehealth
Kenneth Loi, Zhaojun Wang
BioSkeptic
BioSkeptic is a red team for drug-discovery claims.
healthdev tools
Doron Levinson
JL_ai
Flow cytometry underpins immunology and clinical diagnostics, yet its analysis is still bottlenecked by manual gating inside fragmented, subscription-locked GUIs like FlowJo and Cytobank.
healthscienceagents
Louis
Louis is an MCP server + Slack bot that turns a genome-scale CD4⁺ T-cell CRISPRi Perturb-seq screen (Marson/Pritchard 2025) into a discovery-and-memory assistant living inside Claude — no separate app, no API key.
scienceagents
Ricardo Pinho
DJ16
What I built / investigated.
scienceagents
Dabin Jeong
Iptd_Dtmf
Most oncogenic drivers — transcription factors, chromatin modifiers, scaffolds, DNA-repair proteins — are "occupancy-undruggable": they have no pocket a classical inhibitor can bind.
healthscienceagents
Weicheng Li
Sanjana T.
Labs don't sample variants randomly.
science
Sanjana Avinash Taware
Aquiles
Aquiles — auditable, host-directed antiviral target triage for Aedes arboviruses What we built.
healthscienceagents
Marcus Antonio Cardoso Ramalho
MotorSmiths
I rebuilt nature's strongest molecular motor — the phi29 gp16 DNA-packaging ATPase — as a single programmable protein, entirely in silico.
science
Team CoEvo
The standard way to detect interacting proteins (a method called DCA) assumes both organisms evolved together on the same family tree.
healthscience
GeneScope
The Gene Program Interpreter is a Claude Skill for context-aware interpretation of gene programs from Perturb-seq and single-cell data.
scienceagents
Xiaochen Fan
Longevity Nerd
APOE genotype is fixed at birth, yet Alzheimer's appears decades later.
healthscience
Naisha Shah
Data Ingestor
Data Ingestor turns the hours a data curator spends hand-reformatting every CRO's differently-shaped Excel/CSV into a one-click review.
productivityscience
Mesrop Tarkhanyan