Clinibrium
Clinibrium is a clinical decision-support co-pilot for the otoneurology clinic, developed with a subspecialist otolaryngologist.
Core trick
A deterministic red-flag engine sets urgency with escalate-only rules, so the model's output can raise the alert level but never lower it.
Description
Clinibrium is a clinical decision-support co-pilot for the otoneurology clinic, developed with a subspecialist otolaryngologist. It triages a common complaint — vertigo — that hides a rare emergency: posterior-circulation stroke. Its founding guarantee: the model never makes the safety call.
The architecture inverts the usual LLM app — deterministic layers own everything that must be trustworthy. A RedFlagEngine, physically separated from the differential, and hard rails seal the urgency verdict with escalate-only, monotone semantics. A CatBoost + SHAP confidence layer, trained on real clinical cases, doesn't touch urgency — it feeds a recommendation to Claude. Claude reasons over it, grounds its explanation in paraphrased ICVD criteria, and picks its own model (Opus for urgent cases, Sonnet for ambulatory). When Claude catches a subtlety the rules miss, it can raise the alert one level — never lower it. Kill the ML or Claude live and urgency doesn't change; we test exactly that.
Our most creative use of Claude Code is the Safety Harness: a hook that reruns invariant tests whenever Claude edits a safety-critical file and blocks the commit if a guarantee breaks, plus a skill that turns a specialist-signed rule into adversarially-tested code. Twelve invariants, +300 tests, multi-model adversarial audits, tamper-evident FHIR, on-device video. Specialist-reviewed; honestly scoped.
README excerpt
<div align="center"> # Clinibrium ### The model explains. The rails protect. The physician decides. Clinical decision support for the otoneurology clinic, engineered so that **the model never makes the safety call.** [](https://clinibrium.up.railway.app/) [](https://claude.com/claude-code) [](LICENSE) [](#twelve-invariants-safety-you-can-run) [](backend) [](frontend) [](#the-demo-bilingual-reproducible-and-honest) </div> > [!IMPORTANT] > **Research prototype. Not for clinical use.** Clinibrium is built to demonstrate a safety architecture, not to make medical decisions. The safety rails are reviewed by a subspecialist otolaryngologist; the diagnostic weights remain provisional and the system has no prospective clinical validation. See [Scope and honesty](#scope-honesty-and-roadmap). --- <d