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Traxome

Traxome is a deterministic biomedical interpreter: it turns any symptom, gene, variant, or drug into a fully-sourced evidence dossier for patients, clinicians, and researchers.

Code Video Cerebral Valley

Core trick

Unifies 20+ public databases into one query, freezing each result into a content-hashed evidence capsule that re-verifies offline and diffs for reclassifications.

Tags

healthscience

Description

Traxome is a deterministic biomedical interpreter: it turns any symptom, gene, variant, or drug into a fully-sourced evidence dossier for patients, clinicians, and researchers. A single search unifies 20+ public databases — ClinVar, gnomAD, dbNSFP predictors, Open Targets, CPIC, the DEA schedule, openFDA, ClinicalTrials.gov, and more ; and every field traces back to its source. Its core contribution is a Provable Evidence Standard: any result can be frozen into a content-hashed Evidence Capsule that is byte-for-byte reproducible, re-verifiable offline, and diffable over time to flag reclassifications. All ten evidence tools are exposed to Claude over a remote MCP server, giving an AI agent grounded, deterministic, citable biomedical evidence instead of hallucination. This matters because clinical genomics runs on trust: interpretations must be transparent, reproducible, and auditable; exactly what black-box models and paywalled tools fail to deliver.
kkusima/Traxome★ 00 forksPythonNOASSERTIONCreated Jul 9, 2026 · last push Jul 17, 2026

README excerpt

# Traxome™

**Ask about any condition, gene, variant, drug or supplement — get one clear answer, traced to public databases, and reframed for patients, clinicians, or researchers.**

Built for the [Built with Claude — Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences) hackathon.

[![Traxome in action — a Pathogenic variant verdict with the glass-box ACMG explorer, the same variant re-framed for the Patient / Clinician / Researcher lenses, a drug dossier (advil → ibuprofen), the Gene Explorer's interactive 3D protein structure, the live literature feed, and the discovery graph](static/traxome-demo.gif)](https://youtu.be/ViOzwMpICoI)

**▶ [Watch the 2-minute demo on YouTube](https://youtu.be/ViOzwMpICoI)**

## What it does

One search box. Type a **condition** (`migraine`), a **gene** (`CACNA1A`), a **variant** (`BRCA1 R1699W`), a **pharmacogene pair** (`CYP2C19 clopidogrel`), or **anything you can take** — drugs, supplements, herbs, peptides (`advil`, `ashwagandha`). Traxome identifies it and answers through the lens you pick:

- **Patient** — plain-language explainer, side effects and interactions in everyday words, trusted resources (MedlinePlus, Mayo, Cleveland, NHS), and where to find or afford a treatment.
- **Clinician** — full FDA-label detail, real-world safety signal (FAERS), pharmacogenomics (CPIC), and guideline + cash-price links.
- **Researcher** — evidence-ranked risk genes, genetic architecture, and click-through variant analysis with CS

Team