HISTORA
HISTORA is a non-diagnostic, agentic clinical-research navigator built with Claude Code for a clinical/translational researcher.
Core trick
NHANES records are filtered into an eligibility funnel, and a genetic instrument analysis replicated across FinnGen and BioBank Japan tests causal links.
Description
HISTORA is a non-diagnostic, agentic clinical-research navigator built with Claude Code for a clinical/translational researcher. Testing a hypothesis like "does periodontal inflammation share mechanisms with cardiometabolic disease?" normally means weeks of chart review — and often the data isn't even there. HISTORA turns a fragmented public corpus (NHANES) into a research-ready cohort in seconds: an eligibility funnel (20,905 → 442), per-field completeness, and — the differentiator — it states what the data cannot answer (a missing datum is a collection flag, never imputed). It grounds one falsifiable, non-diagnostic hypothesis in genetics it runs live: IL-6R → coronary disease is genetically causal (replicated across FinnGen and BioBank Japan), circulating CRP is not, and the Alzheimer's axis stays exploratory. Operating its own pipeline under a reviewer agent, it caught, retracted, and fixed a bug in its own flagship number (+0.705 → +0.553), with a regression test. It's reproducible, tested, Apache-licensed software a lab can run without us in the room. Why it matters: the mouth is a cheap, modifiable window into the inflammation behind heart disease and diabetes — HISTORA is the instrument to study that link honestly.
README excerpt
# HISTORA — Agentic Clinical Research Navigator **License:** [Apache-2.0](LICENSE) · A **non-diagnostic** research instrument (population-level, hypothesis-generating; not medical advice). <p align="center"> <img src="docs/assets/1p9m_structure.jpeg" width="300" alt="The IL-6 / IL-6Rα / gp130 hexameric signaling complex (PDB 1P9M) — the causal node HISTORA anchors on."/> <br> <sub><b>The causal node.</b> The IL-6 / IL-6Rα / gp130 hexameric signaling complex (PDB <code>1P9M</code>) — where the IL-6R genetic instrument acts and tocilizumab blocks. HISTORA's UniProt/PDB connector renders this live in Claude Science. <i>Image: RCSB PDB (rcsb.org).</i></sub> </p> > A **clinical-research navigator** that turns fragmented clinical data into a **research-ready cohort** — and > tells you honestly **what the data cannot answer**. From a real public corpus (NHANES) it builds an > eligibility funnel, flags every missing datum as a *collection gap it never imputes*, generates a > **falsifiable, uncertainty-quantified hypothesis** (never a conclusion), and exports a preliminary > protocol. Everything it emits is **population/parameter-level, traceable, and non-diagnostic** — a > **research-integrity gate** (sharpest clause: non-diagnostic) enforced by construction, which is what > makes the output citable. > > Its first instantiated payload is the **oral–systemic** question of global interest: is what we can > measure in the mouth — periodontal inflammation — *just a marker*,