1st Place
Billie Gene
Billie Gene is a rapid vaccine-design research acceleration platform built to reduce the early bottleneck in responding to emerging viral outbreaks such as Ebola or Hantavirus.
Core trick
Chains surface-protein ranking, structure modeling, and epitope scoring into a six-step workspace that lays out a concept mRNA construct from a raw sequence.
Description
Billie Gene is a rapid vaccine-design research acceleration platform built to reduce the early bottleneck in responding to emerging viral outbreaks such as Ebola or Hantavirus.
Traditional vaccine discovery can take months before researchers have well-structured candidate designs to evaluate. Billie Gene accelerates this first stage by taking a raw pathogen sequence and running it through an agent-driven scientific workflow that produces research-stage mRNA vaccine candidates in about 10 minutes.
README excerpt
# Billie Gene Billie Gene is a research-use prototype for exploring protein structure modeling in a guided vaccine-design workflow. The frontend is organized as a horizontal step-by-step workspace that moves from sequence intake through surface protein screening, structure modeling, epitope scoring, concept mRNA construct layout, and a final candidate dossier. The prototype is intended for computational exploration and education only. It does not generate clinically validated vaccine products, therapeutic recommendations, or wet-lab-ready protocols. ## Features - Six-step horizontal workflow for sequence intake, surface protein ranking, structure modeling, epitope scoring, mRNA construct preview, and candidate dossier review. - DNA, RNA, protein, and FASTA paste support with local `.txt`, `.fa`, `.fasta`, `.fna`, `.ffn`, `.faa`, `.gb`, and `.gbk` file upload. - Automatic DNA/RNA reading-frame scan that proposes the longest translated protein candidate for folding. - Protein sequence input with the ESM Atlas 400 amino acid limit surfaced in the UI. - Labeled surface protein track viewer with candidate ranking tables. - Live ESM Atlas folding through the public `foldSequence` API. - Local demo model from `esmfold-demo.pdb`. - Browser-based 3D structure viewer using 3Dmol.js. - PDB-derived 2D fallback rendering when WebGL is unavailable. - Epitope heatmap, ranked epitope list, construct diagram, and dossier export queue mockups. ## Project Structure ```text . ├── index.htm