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Clinical Trial Compass

Clinical Trial Compass connects patients' Apple Health data (conditions, health metrics, biomarkers, medications) with the ClinicalTrial.gov database of 500K+ clinical trials using a Claude Agent SDK/Claude Opus 4.6 AI m

Code Video Cerebral Valley

Core trick

Matches Apple Health conditions and medications against ClinicalTrials.gov and openFDA through a six-stage subagent pipeline that can backtrack.

Tags

health

Description

Clinical Trial Compass connects patients' Apple Health data (conditions, health metrics, biomarkers, medications) with the ClinicalTrial.gov database of 500K+ clinical trials using a Claude Agent SDK/Claude Opus 4.6 AI matching agent and companion iOS application. It checks their opt-in shared health history and preferences against this database, as well as an openFDA database of thousands of drugs and interactions to find suitable trials. It moves through a six-stage subagent pipeline (intake, search, matching, selection, report) and can backtrack and take additional turns based on user input. Fewer than 5% of adult cancer patients in the U.S. participate in clinical trials, despite surveys showing that over 70% of patients would be willing to enroll if given the opportunity. The gap isn't reluctance — it's awareness and access. The bridge between clinical trials and the patients who need them is broken. Rebuilding it is one of the highest-impact problems in healthcare today.
jknoll/clinical-trial-copilot★ 00 forksHTMLCreated Feb 11, 2026 · last push Sep 2, 2026

README excerpt

# Clinical Trial Navigator

[![CI](https://github.com/jknoll/clinical-trial-copilot/actions/workflows/ci.yml/badge.svg)](https://github.com/jknoll/clinical-trial-copilot/actions/workflows/ci.yml)

**AI-powered clinical trial guidance for patients and caregivers.**

[![Clinical Trial Compass Trailer](screenshots/Screenshot%202026-02-16%20at%201.21.13%20PM.png)](https://www.youtube.com/watch?v=KC_NnIFLtIM)

▶️ [Watch the trailer on YouTube](https://www.youtube.com/watch?v=KC_NnIFLtIM)

Clinical Trial Navigator transforms the overwhelming experience of searching 450,000+ trials on ClinicalTrials.gov into a personalized, conversational journey. Powered by Claude Opus 4.6, it conducts empathetic patient interviews, searches real clinical trial data, translates dense medical eligibility criteria into plain language, and generates accessible briefing reports for doctor visits.

![Clinical Trial Compass — Web app with stats panel, chat, Apple Health import, and iOS companion](screenshots/Screenshot%202026-02-16%20at%201.21.01%20PM.png)

Built for the **"Built with Opus 4.6" Hackathon** (Cerebral Valley x Anthropic, Feb 2026).

## Why This Exists

ClinicalTrials.gov contains over 450,000 studies, but it was designed for researchers, not patients. Eligibility criteria are written in dense medical language ("ECOG performance status 0-1", "adequate hepatic function as defined by..."), search results are unranked, and there's no way to understand which trials might actually be a good fit

Team